Geert Jan Groeneveld Selected Research

Mitochondrial Diseases (Mitochondrial Disease)

1/2021	Safety, pharmacokinetics and pharmacodynamics of SBT-020 in patients with early stage Huntington's disease, a 2-part study.
1/2020	Brain Bio-Energetic State Does Not Correlate to Muscle Mitochondrial Function in Huntington's Disease.
11/2017	Validation of a pharmacological model for mitochondrial dysfunction in healthy subjects using simvastatin: A randomized placebo-controlled proof-of-pharmacology study.

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Geert Jan Groeneveld Research Topics

Disease

17	Pain (Aches) 01/2023 - 09/2013
9	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2017
8	Parkinson Disease (Parkinson's Disease) 05/2024 - 01/2022
8	Cognitive Dysfunction 12/2023 - 10/2016
4	Respiratory Insufficiency (Respiratory Failure) 01/2022 - 09/2013
4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 08/2009
4	Neuralgia (Stump Neuralgia) 08/2019 - 01/2016
3	Disease Progression 03/2023 - 08/2009
3	Apnea 01/2022 - 01/2017
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 11/2017
2	Inflammation (Inflammations) 01/2022 - 01/2020
2	Neuroinflammatory Diseases 01/2022 - 01/2021
2	Multiple Sclerosis 01/2022 - 01/2020
2	Dementia (Dementias) 01/2022 - 09/2021
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2020 - 01/2018
2	Polyneuropathies (Polyneuropathy) 01/2020 - 04/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2019 - 08/2009
1	Sleepiness 05/2024
1	Fatigue 05/2024
1	Orthostatic Hypotension (Postural Hypotension) 05/2024
1	Mood Disorders (Mood Disorder) 11/2023
1	Depressive Disorder (Melancholia) 11/2023
1	Sleep Deprivation 01/2023
1	Movement Disorders (Movement Disorder) 01/2023
1	Asthenia 01/2022
1	Leukopenia 01/2022
1	Headache (Headaches) 01/2022
1	Syncope (Fainting) 01/2022
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2022
1	Opioid-Related Disorders (Opiate Addiction) 01/2022
1	Hyperhidrosis 01/2021
1	Tremor (Tremors) 01/2020
1	Lennox Gastaut Syndrome 01/2020
1	Diabetic Neuropathies (Diabetic Neuropathy) 01/2020
1	Myoclonic Epilepsies (Myoclonic Encephalopathy) 01/2020
1	Muscular Atrophy (Muscle Atrophy) 01/2019
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/2019
1	Long Term Adverse Effects 01/2019
1	Painful Neuropathy 01/2018
1	Multiple Myeloma 01/2018

Drug/Important Bio-Agent (IBA)

9	Analgesics (Analgesic Drugs)IBA 01/2023 - 01/2016
8	Biomarkers (Surrogate Marker)IBA 11/2023 - 12/2018
8	Cholinergic Agents (Cholinergics)IBA 01/2022 - 10/2016
5	Galantamine (Galanthamine)FDA LinkGeneric 01/2022 - 01/2018
4	Fentanyl (Sublimaze)FDA LinkGeneric 01/2022 - 09/2013
4	Opioid Analgesics (Opioids)IBA 01/2022 - 10/2016
4	Pregabalin (Lyrica)FDA Link 01/2020 - 01/2017
3	Apomorphine FDA Link 05/2024 - 01/2022
3	Ibuprofen (Motrin)FDA LinkGeneric 01/2020 - 01/2017
3	MecamylamineIBA 11/2019 - 01/2018
2	Phosphotransferases (Kinase)IBA 01/2023 - 01/2023
2	Glucosylceramidase (Glucocerebrosidase)IBA 01/2023 - 01/2023
2	Leucine (L-Leucine)FDA Link 01/2023 - 01/2023
2	EnzymesIBA 01/2022 - 04/2010
2	ezogabine (retigabine)IBA 01/2022 - 12/2018
2	Methylphenidate (Ritalin)FDA LinkGeneric 01/2022 - 01/2020
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2022 - 01/2019
2	LigandsIBA 01/2022 - 01/2016
2	Muscarinic M1 ReceptorIBA 11/2021 - 09/2021
2	Huntingtin ProteinIBA 01/2021 - 01/2020
2	Capsaicin (Zostrix)FDA Link 01/2021 - 10/2016
2	Bortezomib (Velcade)FDA Link 01/2020 - 01/2018
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 11/2019 - 11/2018
2	Nicotine FDA Link 11/2018 - 01/2018
1	SolutionsIBA 05/2024
1	Guanosine Monophosphate (5' Guanylic Acid)IBA 12/2023
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2023
1	Soluble Guanylyl CyclaseIBA 12/2023
1	CDw17 antigen (lactosylceramide)IBA 01/2023
1	Glucosylceramides (Glucocerebrosides)IBA 01/2023
1	GlycosphingolipidsIBA 01/2023
1	Voltage-Gated Sodium Channel BlockersIBA 11/2022
1	Buprenorphine (Subutex)FDA LinkGeneric 01/2022
1	mu Opioid Receptors (mu Opioid Receptor)IBA 01/2022
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2022
1	SynucleinsIBA 01/2022
1	Voltage-Gated Sodium ChannelsIBA 01/2022
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 11/2021
1	Apolipoproteins E (ApoE)IBA 01/2021
1	Amyloid (Amyloid Fibrils)IBA 01/2021
1	CytokinesIBA 01/2020
1	Clobazam (HR 376)IBA 01/2020
1	CannabidiolIBA 01/2020
1	NexusIBA 01/2020
1	Sodium Channel BlockersIBA 01/2020
1	PF-05089771IBA 01/2020
1	Sodium Channels (Sodium Channel)IBA 01/2020
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2020
1	PF-06372865IBA 08/2019
1	Messenger RNA (mRNA)IBA 01/2019
1	RG7800IBA 01/2019
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2019
1	Donepezil (Aricept)FDA LinkGeneric 01/2019
1	Proteins (Proteins, Gene)FDA Link 01/2019
1	Riluzole FDA LinkGeneric 12/2018

Therapy/Procedure

4	Analgesia 01/2021 - 09/2013
3	Therapeutics 01/2023 - 01/2018
2	Subcutaneous Injections 05/2024 - 01/2022
1	Injections 01/2022
1	Surgical Instruments (Clip) 01/2020